Purified Mouse Monoclonal Antibody
| 货号 | 规格 | 价格 |
|---|---|---|
| M900002 | ||
| 100µL | ¥1780.00 | |
| 50µL | ¥1080.00 | |
| 20µL | ¥588.00 |
| Product Name | Anti-ZO-1 Mouse mAb |
|---|---|
| Description | Purified Mouse Monoclonal Antibody |
Application
|
WB, IF |
| Dilution | WB 1:1,000~1:5,000; IF:1:500~1:1,000 |
| Reactivity | Human, Mouse, Rat, Canis |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone No. | 24D02C18 |
| Isotype | IgG |
| Target / Specificity | This ZO-1 antibody is generated from mice immunized with a SHC (Shrimp Hemocyanin) conjugated synthetic peptide between 39-53 amino acids from homo sapiens (Human). |
| Format | Purified monoclonal antibody supplied in PBS with 0.01% sodium azide and 50% glycerol, pH 7.3. This antibody is purified through a protein G column. |
| Gene ID | 7082 |
|---|---|
| Synonyms | Tight junction protein 1; Tight junction protein ZO-1; Tight junction protein ZO1 |
| Calculated MW | 230 kDa |
| Primary Accession | Q07157 |
| Antigen Region | 39-53 aa |
| Storage | Shipped at 4℃. Upon delivery aliquot. Store at 4℃ short term (1~2 weeks). Store at -20℃ for 2 years. Avoid freeze / thaw cycles. |
| Precautions | Anti-ZO-1 Mouse mAb is for research use only and not for use in diagnostic or therapeutic procedures. |
| Background | ZO-1 forms complexes with either ZO-2 or ZO-3. In addition, these proteins can also associate with claudin, occludin and F-actin, at tight junction stands, where they provide a linkage between the actin cytoskeleton and the tight junction. ZO-1 expression is significantly reduced in many breast cancer lines. ZO-2 and ZO-3 are ubiquitously expressed within epithelial tight junctions, and unlike ZO-1, which is also expressed at cell junctions of cardiac myocytes, ZO-2 is not expressed in nonepithelial tissue. ZO-1 is a protein located on a cytoplasmic membrane surface of intercellular tight junctions. ZO-1 may be involved in signal transduction at cell-cell junctions. Two transcript variants encoding distinct isoforms have been identified for the ZO-1 gene. Diseases associated with ZO-1 dysfunction include Celiac Disease and Congenital Nephrotic Syndrome. |
|---|
| Cellular Location | Cell membrane. Cell junction > tight junction. Movement of ZO-1 from the cytoplasm to membrane is an early event occurring concurrently with cell-cell contact. |
|---|
| Tissue Location | The alpha-containing isoform is found in most epithelial cell junctions. The short isoform is found both in endothelial cells and the highly specialized epithelial junctions of renal glomeruli and Sertoli cells of the seminiferous tubules. |
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